The first preprint from our group is now online at bioRxiv:
In the preprint, we present evidence that many species have intrinsic base substitution patterns that are quite similar to one another, and to mutational signature 5 in human cancers. We also show that a similar pattern is produced when single-stranded DNA in yeast is damaged, and that the damage depends on sugar metabolism. These results suggest that energy metabolism is directly linked to the continuous generation of genetic diversity in organisms. In other words, the processes that generate energy to keep cells alive will necessarily also produce mutations, which are the starting material for evolution by natural selection.